Blog
Articles on longevity, preventive medicine and wellbeing.
Sarcopenia: The Muscle Loss That Accelerates Aging
Sarcopenia is the progressive loss of muscle mass, strength, and function associated with aging. It starts earlier than you think and compromises your independence, metabolism, and ability to recover.
Metformin and Longevity: What Science Says in 2026
Metformin, a widely used antidiabetic drug, is being investigated as a longevity tool. Learn the scientific evidence, mechanisms, and whether it makes sense for you.
Melatonin and Aging: What Science Says About Sleep, Antioxidants, and Longevity
Is melatonin only a sleep aid, or does it also affect ageing? What the evidence says about sleep, antioxidant biology, risks, and the real limits.
Gut microbiome and longevity: how the gut shapes aging
How gut microbiome and longevity are connected, what centenarian studies actually show, and which habits have the best support for healthy aging.
Menopause and Longevity: When HRT Protects Your Healthspan
Menopause changes bone, muscle, sleep, and cardiovascular risk. Here you can see when HRT makes sense, what it may improve, and what to measure before deciding.
How Much Does a Longevity Clinic Cost: 2026 Price Guide
Short answer: €500 to €1,500 per night for integrated clinics, €3,000 to €8,000 per night for premium operators, and €5,000 to €15,000 for diagnostics-only centers without accommodation. Here is what actually drives the bill.
Why Valencia Is Becoming a Longevity Hub in Europe
Valencia combines Mediterranean nutrition, international access, natural surroundings and serious medical infrastructure. That is how a real longevity hub is built.
Healthspan vs lifespan: why living longer isn't enough
Healthspan is the period of life spent in good health. Spain has 84 years of life expectancy but only 72 healthy years. Those 12 years of difference change everything about how we think about longevity.
The 12 Hallmarks of Aging: What They Are and What You Can Do About Each One
The hallmarks of aging are 12 biological processes that drive age-related decline. From genomic instability to dysbiosis, we review the evidence and the interventions available today.
How to Choose a Longevity Clinic: 10 Criteria You Must Evaluate
The longevity market grows 8% per year, but not all clinics deliver the same value. These 10 criteria help you tell evidence-based medicine from marketing dressed up as science.
Senolytics: the science of eliminating the zombie cells that age you
Senolytics selectively destroy senescent cells that accelerate aging. From mice to the first human trials: what the science says and what you can do today.
Intermittent Fasting and Autophagy: Your Science-Based Guide to Cellular Cleanup
Autophagy is the cellular recycling system that removes damaged proteins, broken mitochondria and pathogens. Intermittent fasting is its most powerful natural trigger. A guide with protocols, studies and strategies to integrate it into your longevity plan.
Menopause and Weight Gain: Why It Happens and What Actually Works
Menopause isn't just hot flashes. Hormonal changes shift fat to your belly, reduce muscle mass, and alter your metabolism. Here's why you're gaining weight—and what science says actually works.
Therapeutic Fasting: What It Is, How It Works and What the Science Says
Therapeutic fasting isn't a diet — it's a medically supervised metabolic reset that activates autophagy, improves insulin sensitivity, and reduces inflammation. Complete guide on fasting types, biological mechanisms (AMPK, mTOR, sirtuins), evidence-backed benefits, contraindications, and how we apply it at Progevita.
Volcanic Water and Longevity: The Science of Mineral Balneotherapy
Mineral composition, action mechanisms and scientific evidence for volcanic thermal therapy. 120 years of tradition at Cofrentes in the service of longevity.
Epigenetic Clocks: Biological Age vs Chronological Age
Epigenetic clocks measure your real biological age via DNA methylation. How Horvath, GrimAge and DunedinPACE work — and how to slow your aging rate.
Inflammaging: Chronic Inflammation and Accelerated Aging
What is inflammaging, how it ages you from within, and science-backed strategies to slow it down. Complete guide with biomarkers, tests and treatments.
Anti-Inflammatory Diet: Evidence-Based Guide for Longevity
An anti-inflammatory diet reduces chronic inflammation markers linked to aging. Evidence-based guide: foods, mechanisms, Mediterranean weekly menu, and integration with medical treatments.
What Is a Longevity Clinic, How It Works and What It Costs
A longevity clinic is a medical center that optimizes healthspan with biomarkers, evidence-based treatments, and follow-up. Here is what it does and how it differs from a spa.
Vive Más 2026: longevity retreat with Marcos Vázquez at Progevita
Inside Vive Más 2026: four days of science, training and health assessment with Marcos Vázquez (Fitness Revolucionario), Borja Bandera, Matías Mut and Antonio Valenzuela at our health resort in Valencia, Spain.
Perimenopause: Symptoms, Duration, and How to Prepare
Perimenopause is not menopause — it's the hormonal transition that can last up to 10 years. Complete guide on symptoms (beyond hot flashes), key biomarkers, and evidence-based treatment options: hormone therapy, exercise, nutrition, and advanced therapies.
Preventive Medicine: What It Is, How It Works, and Why It Matters
Preventive medicine stops diseases before they start, catches them early, and reduces their impact. Learn how it works, its three levels, and how it connects to longevity medicine.
Cellular Senescence: What It Is and How It Drives Aging
Cellular senescence is the state in which a cell permanently stops dividing but does not die, instead releasing inflammatory signals that damage surrounding tissue and accelerate aging.
Sirtuins: What They Are, What They Do and Why NAD+ Matters
What sirtuins are, how they depend on NAD+, and why they matter for longevity, metabolism, and inflammation. A clear guide to SIRT1-7 with real evidence.
Mitochondrial Dysfunction and Aging: What Happens Inside Your Energy Factories
Mitochondrial dysfunction is the progressive loss of ATP production efficiency that occurs with age, accompanied by increased oxidative stress and chronic inflammation. It is one of the 12 hallmarks of aging.
Therapeutic Plasma Exchange (TPE): What It Is, How It Works, and the Science of Biological Age Reversal
Therapeutic plasma exchange reduces biological age by up to 2.6 years according to clinical trials. Learn what TPE is, how it works, its longevity benefits, and why it removes microplastics and inflammation.
Plasmapheresis: how it works, step by step, and what to expect
Plasmapheresis is a blood filtration procedure that separates and removes inflammatory proteins from plasma. Full guide to the process, duration, effects and recovery.
NAD+ Therapy: What It Is, What It Is For and How It Works
NAD+ therapy helps restore a coenzyme that declines with age and influences energy, DNA repair, and mitochondrial function. A practical guide to uses, routes, and limits.
Ozone Therapy: Benefits, Evidence and What to Expect
Ozone therapy uses a controlled oxygen-ozone mix to reduce inflammation, modulate the immune system and improve tissue oxygenation. Here's what the science actually says.
Longevity Biomarkers: What to Track, How Often and Why
Which biomarkers to track to see how you are actually aging, how often to repeat them, and which ones matter most for healthspan and risk.
The latest advances in hormone therapy: how women's health is changing in 2025-26
Far from being a simple end of menstruation, menopause marks a deep biological transition with significant long-term implications for women's health.
The Impact Project X Progevita
In a business environment shaped by speed, uncertainty, and sustained demand, companies are seeking to strengthen leadership from a more human, healthy, and strategic perspective.
The Coolest Longevity & Health Event of the Year Lands at Progevita (Valencia): LBF7 Spain
From September 22–29, 2025, the Longevity Biotech Fellowship (LBF) comes to Spain, turning Balneario de Cofrentes – Progevita into the international hub of longevity.
A Special Retreat with Elena Devís: Science, Mindfulness and Longevity at Progēvita
A few weeks ago, we hosted a truly special retreat at Progēvita in collaboration with Elena Devís, founder of Positivamente Presente. For the 26 participants, it was far more than a medical program.
Why we launch Progēvita
My parents are physicians and have been running a large family-owned clinic for 30 years. When I incorporated to the family business already 15 years ago, I agreed with my father that I would not just operate the business he had founded but make it my vision.
Don't die
For some people Bryan Johnson might be an eccentric millionaire, his methodology might be questionable, even his business model is dubious, but over the last few years he has become an incredible asset to the longevity field.
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